Reconstruction of Human Blood-brain-barrier in a Vascularized Brain Organoid Model for in vitro Study of Brain Vascular Disease Blood-brain-barrier (BBB) is one of critical functional units in our brains, which not only allows oxygen, nutrient/waste and inductive...
Live Cell Imaging of Mitochondria and Actin Dynamics During Synaptogenesis In vitro and in vivo studies have shown that neurons can undergo neuritogenesis and synaptogenesis in response to various compounds that are being tested in the clinic for treating various...
Mechanistic studies into the cognitive rescue effect of pioglitazone in chronic TBI Traumatic Brain Injury (TBI) is a leading cause of long-term disability in people of all ages. Although the full pathophysiology that leads to brain dysfunction in long-term TBI is not...
Targeting Astrocytes to Enhance Synaptic Plasticity and Repair This project investigates the molecular mechanisms that control neuronal synaptic plasticity and remodeling during the critical period, a period of time in the developing brain when it is possible to...
Cell type-specific molecular and epigenetic impacts of stress on aminergic neurons Biogenic amines, such as serotonin, dopamine, and norepinephrine, are key regulators of stress responses. As such, many drugs classified as antidepressants target proteins that regulate...
