Functional Significance of DEK in Alzheimer’s Disease and Age-Related Dementias This LIFE proposal tests the overarching hypothesis that the chromatin-remodeling nuclear phosphoprotein, DEK, is an important cognitive protective factor in the brain and that its...
Mechanisms of enhanced autophagy protecting healthy aging of neural stem cells Adult stem cells are responsible for the lifelong generation, maintenance, and repair of tissue and organ systems, and therefore are both useful models to study cellular aging and...
Single Cell Characterization of Epigenetic Mechanisms Underlying Cocaine Craving Addiction is a chronic, relapsing mental disease that has profound familial and societal impact. The Centers for Disease Control and Prevention (CDC) report that more than half a million...
Inhibition of Drp1 using a selective Drp1 peptide inhibitor for treatment of alpha-synuclein associated Parkinson’s Disease Our long-term goal is to gain mechanistic insights of mitochondrial dysfunction into the pathogenesis of Parkinson’s disease (PD) and to...
Identifying the genetic risk underlying poor cognitive recovery after traumatic brain injury Traumatic brain injury (TBI) affects 2.8 million people in the United States annually,1 many of whom have untreated impaired cognitive recovery. While injury factors are...
