Cell type-specific molecular and epigenetic impacts of stress on aminergic neurons Biogenic amines, such as serotonin, dopamine, and norepinephrine, are key regulators of stress responses. As such, many drugs classified as antidepressants target proteins that regulate...
Functional Significance of DEK in Alzheimer’s Disease and Age-Related Dementias This LIFE proposal tests the overarching hypothesis that the chromatin-remodeling nuclear phosphoprotein, DEK, is an important cognitive protective factor in the brain and that its...
Mechanisms of enhanced autophagy protecting healthy aging of neural stem cells Adult stem cells are responsible for the lifelong generation, maintenance, and repair of tissue and organ systems, and therefore are both useful models to study cellular aging and...
